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2-(Ethoxymethylene)propanedinitrile → 3,7-dip-tolyl-3H-imidazo[4,5-b]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Ethoxymethylene)propanedinitrile | HCID 67152 | — |
| 反応物 | N2,4-dip-tolylpyridine-2,3-diamine | HCID 86622263 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 3,7-dip-tolyl-3H-imidazo[4,5-b]pyridine | HCID 68557882 | 84% |
反応手順
0.70 mol of N2,4-dip-tolylpyridine-2,3-diamine and 2.56 mol of 2-(ethoxymethylene)malonnitrile were added in 10 ml of isopropanol, and refluxed for 6 hours. The solution was removed and was purified by using column chromatography to thereby produce a solid crystalline product at a yield of 84%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745020B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-28dfca87989749a49ff2d38ea0776f26 |
| 出典メモ | uspto-grants-2010_06 |