6-((4-Bromophenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamide → HCID 66988803、化合物

HRID 1944891ノート

反応式

HRID 1944891 の反応式
[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6](C2C=CC=C(S(C3C=C4C(=C(C)C=3)N=CC(C(N)=O)=C4NC3C=CC=C(OC)C=3)(=O)=O)C=2)=[CH:5][CH:4]=1.Br[C:42]1[CH:47]=[CH:46][C:45]([S:48]([C:51]2[CH:52]=[C:53]3[C:58](=[C:59]([CH3:61])[CH:60]=2)[N:57]=[CH:56][C:55]([C:62]([NH2:64])=[O:63])=[C:54]3[NH:65][C:66]2[CH:71]=[CH:70][CH:69]=[C:68]([O:72][CH3:73])[CH:67]=2)(=[O:50])=[O:49])=[CH:44][CH:43]=1>>[OH:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:42]2[CH:47]=[CH:46][C:45]([S:48]([C:51]3[CH:52]=[C:53]4[C:58](=[C:59]([CH3:61])[CH:60]=3)[N:57]=[CH:56][C:55]([C:62]([NH2:64])=[O:63])=[C:54]4[NH:65][C:66]3[CH:71]=[CH:70][CH:69]=[C:68]([O:72][CH3:73])[CH:67]=3)(=[O:50])=[O:49])=[CH:44][CH:43]=2)=[CH:5][CH:4]=1

参加物

3

反応物 2

HCID 669882586-((4-Bromophenyl)sulfonyl)-4-((3-methoxyphenyl)amino)-8-methylquinoline-3-carboxamideHCID 66988923HCID 66988923、化合物

生成物 1

HCID 66988803HCID 66988803、化合物収率 77%

実験手順

The title compound was synthesized in a manner analogous to that described for Intermediate 64, using Intermediate 63 (1.38 mmol) as substrate. The crude product was triturated in 15 mL of ethyl acetate for 10 min. After cooling to room temperature, the suspension was recovered by filtration and washed with ethyl acetate to give the title compound as a yellowish solid (591 mg, 77% for 3 steps). ES/MS calcd. for C31H28N3O5S+ 554.2. Found m/z=554.3 (M+H)+.

後処理

  1. customThe title compound was synthesized in a manner analogous to
  2. customThe crude product was triturated in 15 mL of ethyl acetate for 10 min
  3. filtrationthe suspension was recovered by filtration
  4. washwashed with ethyl acetate

出典と根拠

ORDレコード
ord-8defdb65aecd4e0d9ffe7946f7300864
出典データセット
uspto-grants-2013_03
特許番号
US08394829B2

反応ノート

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