Potassium Carbonate → 4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]-1-methoxy-benzene

HRID 1945185ノート

反応式

HRID 1945185 の反応式
C(=O)([O-])[O-].[K+].[K+].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([O:15][CH3:16])=[C:12]([SH:14])[CH:13]=1.[CH2:17]([S:19]([C:22]1[CH:27]=[CH:26][C:25](Br)=[CH:24][CH:23]=1)(=[O:21])=[O:20])[CH3:18]>CN1C(=O)CCC1>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]([O:15][CH3:16])=[C:12]([S:14][C:25]2[CH:24]=[CH:23][C:22]([S:19]([CH2:17][CH3:18])(=[O:21])=[O:20])=[CH:27][CH:26]=2)[CH:13]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 115723521-Bromo-4-(ethanesulfonyl)benzeneHCID 127727855-Chloro-2-methoxybenzene-1-thiol

生成物 1

HCID 669957324-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]-1-methoxy-benzene

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
90 °C

実験手順

Potassium carbonate (0.315 g) was added to a stirred solution of the product from step (i) (0.4 g) and ethyl-(4-bromo-phenyl)-sulfone (0.285 g) in NMP (10 ml) and the mixture heated at 90° C. for 1 h. The mixture was partitioned between water/ethylacetate, the organics separated, dried, and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 25% ethylacetate/isohexane. Yield 0.4 g

後処理

  1. customThe mixture was partitioned between water/ethylacetate
  2. customthe organics separated, dried
  3. customevaporated under reduced pressure
  4. customThe residue was purified by chromatography on silica eluting with 25% ethylacetate/isohexane

出典と根拠

ORDレコード
ord-0296843d911b42d2bf38783602ac307a
出典データセット
uspto-grants-2013_03
特許番号
US08394986B2

反応ノート

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