Potassium Carbonate → [4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, 1,1-dimethylethyl ester

HRID 1945187ノート

反応式

HRID 1945187 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([S:9][C:10]2[CH:15]=[CH:14][C:13]([S:16]([CH2:19][CH3:20])(=[O:18])=[O:17])=[CH:12][CH:11]=2)[CH:3]=1.[C:21]([O:25][C:26](=[O:29])[CH2:27]Br)([CH3:24])([CH3:23])[CH3:22].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:27][C:26]([O:25][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:29])=[C:4]([S:9][C:10]2[CH:11]=[CH:12][C:13]([S:16]([CH2:19][CH3:20])(=[O:17])=[O:18])=[CH:14][CH:15]=2)[CH:3]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 79177tert-Butyl bromoacetateHCID 669960804-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]-phenol

生成物 1

HCID 86659304[4-Chloro-2-[[4-(ethylsulfonyl)phenyl]thio]phenoxy]-acetic acid, 1,1-dimethylethyl ester

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A mixture of the product from step (iii) (0.3 g), tert-butylbromoacetate (0.15 ml) and potassium carbonate (0.13 g) in DMF (20 ml) was stirred at RT overnight. The mixture was partitioned between water and ethylacetate, the organics separated, dried, and evaporated under reduced pressure. Yield 0.55 g

後処理

  1. customThe mixture was partitioned between water and ethylacetate
  2. customthe organics separated, dried
  3. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-bf0738449cd443e38942eb8572d0aff4
出典データセット
uspto-grants-2013_03
特許番号
US08394986B2

反応ノート

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