3-(2-Methylpropyl)pyrrolidine → 4-(8-((3-isobutylpyrrolidin-1-yl)methyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

HRID 1945870

反応式

HRID 1945870 の反応式
Br[CH2:2][C:3]1[N:4]([CH3:28])[C:5]2[C:10]([N:11]=1)=[C:9]([N:12]1[CH2:17][CH2:16][O:15][CH2:14][CH2:13]1)[N:8]=[C:7]([N:18]1[C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=3[N:20]=[C:19]1[CH3:27])[N:6]=2.[CH2:29]([CH:33]1[CH2:37][CH2:36][NH:35][CH2:34]1)[CH:30]([CH3:32])[CH3:31]>>[CH2:29]([CH:33]1[CH2:37][CH2:36][N:35]([CH2:2][C:3]2[N:4]([CH3:28])[C:5]3[C:10]([N:11]=2)=[C:9]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:8]=[C:7]([N:18]2[C:22]4[CH:23]=[CH:24][CH:25]=[CH:26][C:21]=4[N:20]=[C:19]2[CH3:27])[N:6]=3)[CH2:34]1)[CH:30]([CH3:32])[CH3:31]

参加物

3

反応物 2

HCID 229753323-(2-Methylpropyl)pyrrolidineHCID 596058124-(8-(bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

生成物 1

HCID 596056644-(8-((3-isobutylpyrrolidin-1-yl)methyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine

実験手順

4-(8-(Bromomethyl)-9-methyl-2-(2-methyl-1H-benzo[d]imidazol-1-yl)-9H-purin-6-yl)morpholine (50 mg) was reacted with 3-isobutylpyrrolidine via General Procedure E to give 27 mg of 302 following reverse phase purification. MS (Q1) 489.2 (M)+

後処理

  1. customto give
  2. custom27 mg of 302 following reverse phase purification

出典と根拠

ORDレコード
ord-8e2866f3db16420784cf3044b8fa2eab
出典データセット
uspto-grants-2013_03
特許番号
US08394796B2

関連ノート

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