2-(Propan-2-yl)-2,3-dihydro-1H-indazol-3-one → 1-(8-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-9-methyl-6-morpholino-9H-purin-2-yl)-2-isopropyl-1H-indazol-3(2H)-one

HRID 1945964ノート

反応式

HRID 1945964 の反応式
[CH:1]([N:4]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[NH:5]1)([CH3:3])[CH3:2].Cl[C:15]1[N:23]=[C:22]2[C:18]([N:19]=[C:20]([CH2:25][N:26]3[CH2:31][CH2:30][CH:29]([C:32]([OH:35])([CH3:34])[CH3:33])[CH2:28][CH2:27]3)[N:21]2[CH3:24])=[C:17]([N:36]2[CH2:41][CH2:40][O:39][CH2:38][CH2:37]2)[N:16]=1>>[OH:35][C:32]([CH:29]1[CH2:28][CH2:27][N:26]([CH2:25][C:20]2[N:21]([CH3:24])[C:22]3[C:18]([N:19]=2)=[C:17]([N:36]2[CH2:37][CH2:38][O:39][CH2:40][CH2:41]2)[N:16]=[C:15]([N:5]2[C:6]4[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=4)[C:12](=[O:13])[N:4]2[CH:1]([CH3:3])[CH3:2])[N:23]=3)[CH2:31][CH2:30]1)([CH3:34])[CH3:33]

参加物

3

反応物 2

HCID 513613212-(Propan-2-yl)-2,3-dihydro-1H-indazol-3-oneHCID 596034262-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol

生成物 1

HCID 596054321-(8-((4-(2-hydroxypropan-2-yl)piperidin-1-yl)methyl)-9-methyl-6-morpholino-9H-purin-2-yl)-2-isopropyl-1H-indazol-3(2H)-one

実験手順

Following General Procedure I for Buchwald coupling, 2-isopropyl-1,2-dihydroindazol-3-one and 2-(1-((2-chloro-9-methyl-6-morpholino-9H-purin-8-yl)methyl)piperidin-4-yl)propan-2-ol were reacted to give 443. LCMS m/z: 549.3 (MH+)

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-79a790d17b3248e5bd9c64c99464ce19
出典データセット
uspto-grants-2013_03
特許番号
US08394796B2

反応ノート

読み込み中…