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N,4-Dimethylcyclohexanamine → N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,4-Dimethylcyclohexanamine | HCID 4962029 | — |
| 反応物 | 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | HCID 59447105 | — |
| 生成物 | N-(4-hydroxy-2-methylphenyl)-6-[methyl(4-methylcyclohexyl)amino]pyrimidine-4-carboxamide | HCID 25182771 | — |
反応手順
Following the general method as outlined in Example 20, starting from 6-chloro-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide (Intermediate 8) and N,4-dimethylcyclohexanamine (Enamine), the title compound was obtained as a mixture of cis-trans stereoisomers, as a yellow solid after purification by column chromatography (silica) eluting with cyclohexane containing increasing amounts of EtOAc.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08399448B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-bb1a575b101f4891b0807757b3fbb061 |
| 出典メモ | uspto-grants-2013_03 |