化工社化工社 化学情報印刷レポート · 研究参考用
N-(2-methoxyethyl)cyclohexanamine → N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclohexyl(2-methoxyethyl)amino]pyrimidine-4-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-methoxyethyl)cyclohexanamine | HCID 12687399 | — |
| 反応物 | 6-Chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)amide | HCID 59447056 | — |
| 生成物 | N-[4-(aminosulfonyl)-2-methylphenyl]-6-[cyclohexyl(2-methoxyethyl)amino]pyrimidine-4-carboxamide | HCID 25182783 | 82% |
反応手順
Following the general method as outlined in Example 20, starting from 6-chloro-pyrimidine-4-carboxylic acid (2-methyl-4-sulfamoyl-phenyl)-amide (Intermediate 17) and cyclohexyl-(2-methoxy-ethyl)-amine (Intermediate 26), the title compound was obtained as a white solid in 82% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08399448B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-dc7140b8799e4b6ba0bc897e288a2634 |
| 出典メモ | uspto-grants-2013_03 |