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1,4-Dioxane hydrochloride → 5-(2,4-Dihydroxy-5-isopropylphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

HRID 1947212
ノート
印刷プレビュー

反応式

HRID 1947212 の反応式
Cl.O1CCOCC1.[CH:8]([C:11]1[C:12]([O:41]COC)=[CH:13][C:14]([O:37]COC)=[C:15]([C:17]2[N:18]([C:23]3[CH:28]=[CH:27][C:26]([CH2:29][N:30]4[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]4)=[CH:25][CH:24]=3)[C:19](=[O:22])[NH:20][N:21]=2)[CH:16]=1)([CH3:10])[CH3:9]>CO>[OH:37][C:14]1[CH:13]=[C:12]([OH:41])[C:11]([CH:8]([CH3:10])[CH3:9])=[CH:16][C:15]=1[C:17]1[N:18]([C:23]2[CH:24]=[CH:25][C:26]([CH2:29][N:30]3[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]3)=[CH:27][CH:28]=2)[C:19](=[O:22])[NH:20][N:21]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 598298715-(5-Isopropyl-2,4-bis-methoxymethoxyphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

生成物 1

HCID 1359070425-(2,4-Dihydroxy-5-isopropylphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
40 °C

実験手順

At room temperature, 4 N hydrochloric acid/1,4-dioxane solution (5 mL) was added to a methanol (5 mL) solution of 5-(5-isopropyl-2,4-bis-methoxymethoxyphenyl)-4-[4-(4-methyl piperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one (F652-09, 644 mg, 1.26 mmol). After stirring at 40° C. for 1 hour, the solvent was distilled off under reduced pressure. Methanol was added to the crude product thus obtained, and the resulting suspension was stirred at room temperature. The precipitated solid was collected by filtration to obtain 5-(2,4-dihydroxy-5-isopropylphenyl)-4-[4-(4-methylpiperazin-1-ylmethyl)phenyl]-2,4-dihydro-[1,2,4]triazol-3-one (OH-a13) dihydrochloride (white solids).

後処理

  1. distillationthe solvent was distilled off under reduced pressure
  2. additionMethanol was added to the crude product
  3. customthus obtained
  4. stirringthe resulting suspension was stirred at room temperature
  5. filtrationThe precipitated solid was collected by filtration

出典と根拠

ORDレコード
ord-f8309d77c0494fc7b46e66720e4179dc
出典データセット
uspto-grants-2013_03
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08399464B2

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート