Methylamine → HCID 67254135、化合物

HRID 1947949ノート

反応式

HRID 1947949 の反応式
[C:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[C:5]=1[C:6](OC)=[O:7])(=[O:3])[CH3:2].[CH3:17][NH2:18]>C(O)C>[OH:3][C:1]1([CH3:2])[C:4]2[C:5](=[C:10]([N+:14]([O-:16])=[O:15])[CH:11]=[CH:12][CH:13]=2)[C:6](=[O:7])[N:18]1[CH3:17]

参加物

4

反応物 2

HCID 6329MethylamineHCID 59644399Methyl 2-acetyl-6-nitrobenzoate

生成物 1

HCID 67254135HCID 67254135、化合物収率 85%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of methyl 2-acetyl-6-nitrobenzoate (2 g, 8.96 mmol) and 33% methylamine in ethanol (10 mL) was stirred at reflux for 14 h. The solvents were removed under reduced pressure to afford 1.7 g of the desired product (yield: 85%). 1H NMR (CDCl3, 300 MHz): δ=1.80 (s, 3H), 3.05 (s, 3H), 7.78 (m, 2H), 7.95 (m, 1H).

後処理

  1. temperatureat reflux for 14 h
  2. customThe solvents were removed under reduced pressure

出典と根拠

ORDレコード
ord-18d90228b2134a4dab9871f9e5d7b253
出典データセット
uspto-grants-2013_03
特許番号
US08399433B2

反応ノート

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