Acetone → HCID 69344871、化合物

HRID 1948253ノート

反応式

HRID 1948253 の反応式
[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][NH:6][C:7]2=[O:12].[CH3:13][C:14]([CH3:16])=O>>[Cl:1][C:2]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][N:6]([CH2:13][CH2:14][CH3:16])[C:7]2=[O:12]

参加物

3

反応物 2

HCID 180AcetoneHCID 218898205-chloroisoquinolin-1(2H)-one

生成物 1

HCID 69344871HCID 69344871、化合物収率 40%

実験手順

According to Scheme 28 Step 3: The title compound was prepared from 5-chloroisoquinolin-1(2H)-one (1 eq, 2.66 mmol, 0.48 g) and 1-bromopropyl (1.1 eq, 2.93 mmol, 0.27 mL) according to the procedure described for Example 1 Step 2. Reaction conditions: microwaved at 150° C. for 60 min. in acetone. The crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2) using pure CH2Cl2 to afford 5-chloro-2-propylisoquinolin-1(2H)-one (1.06 mmol, 0.24 g, 40%) as an orange solid.

後処理

  1. customReaction conditions
  2. customThe crude product was purified by flash chromatography over silica gel (AIT Flashsmart prepacked column 25 g SiO2)

出典と根拠

ORDレコード
ord-92ecdef2bf2e45cab99a02c52454a44a
出典データセット
uspto-grants-2013_03
特許番号
US08399493B2

反応ノート

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