Dichloromethane → Methyl 2-chloro-4,4-dimethoxy-3-oxopentanoate

HRID 1948360ノート

反応式

HRID 1948360 の反応式
[CH3:1][O:2][C:3]([O:12][CH3:13])([CH3:11])[C:4](=[O:10])[CH2:5][C:6]([O:8][CH3:9])=[O:7].C(Cl)[Cl:15]>>[Cl:15][CH:5]([C:4](=[O:10])[C:3]([O:2][CH3:1])([O:12][CH3:13])[CH3:11])[C:6]([O:8][CH3:9])=[O:7]

参加物

3

反応物 2

HCID 6344DichloromethaneHCID 5076552Methyl 4,4-dimethoxy-3-oxopentanoate

生成物 1

HCID 59208484Methyl 2-chloro-4,4-dimethoxy-3-oxopentanoate

実験手順

SO2Cl2 (2.2 ml, 27 mmol) was added slowly to a solution of 5.0 g (26 mmol) of methyl 4,4-dimethoxy-3-oxopentanoate in 30 ml CH2Cl2 cooled in an ice water bath. The solution was warmed to room temperature and stirred for 1 h. Solvent was removed and the residue was taken up in EtOAc, which was washed with water and brine. Drying (MgSO4) and removal of solvent gave 6.1 g of an oil. NMR: (CDCl3): 1.5 (s, 3H), 3.25 (2s, 6H), 4.8 (s, 3H), 5.3 (s, 1H).

後処理

  1. temperaturecooled in an ice water bath
  2. customSolvent was removed
  3. washwhich was washed with water and brine
  4. customDrying
  5. custom(MgSO4) and removal of solvent

出典と根拠

ORDレコード
ord-91090372fce14ae09617144ab9b3b6dc
出典データセット
uspto-grants-2013_03
特許番号
US08399489B2

反応ノート

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