tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate → 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylic acid

HRID 1948377ノート

反応式

HRID 1948377 の反応式
[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:16]([O:18]C(C)(C)C)=[O:17])[N:5]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:15])([CH3:14])[CH3:13])[C:6]=1[CH3:7]>CN1CCCC1=O>[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:16]([OH:18])=[O:17])[N:5]([CH2:8][O:9][CH2:10][CH2:11][Si:12]([CH3:14])([CH3:15])[CH3:13])[C:6]=1[CH3:7]

参加物

3

反応物 1

HCID 68516579tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate2 回

生成物 1

HCID 685160854-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylic acid

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
200 °C

実験手順

tert-butyl 4-chloro-3-fluoro-5-methyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrrole-2-carboxylate (Intermediate 264, 100 mg) was dissolved in N-methylpyrrolidinone (10 ml), heated to 200° C. for 30 minutes. The resulting solution was carried on to the next step without further purification.

後処理

  1. customThe resulting solution was carried on to the next step without further purification

出典と根拠

ORDレコード
ord-447cf5db8bda49e8be118a8d969ff446
出典データセット
uspto-grants-2013_03
特許番号
US08399489B2

反応ノート

読み込み中…