Triethylamine → 2-(2-Phenylpropyl)imidazolidin-4-one
反応式
[C:1]1([CH:7]([CH3:11])[CH2:8][CH:9]=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:13][CH2:14][C:15]([NH2:17])=[O:16].C(N(CC)CC)C.C([O-])([O-])=O.[K+].[K+]>C(O)C>[C:1]1([CH:7]([CH3:11])[CH2:8][CH:9]2[NH:17][C:15](=[O:16])[CH2:14][NH:13]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1参加物
6
反応条件
- 温度
- 60 °C
実験手順
A mixture of 3-phenylbutanal (Trifernal®, 0.67 g, 4.5 mmol), glycinamide hydrochloride (0.50 g, 4.5 mmol), triethylamine (0.46 g, 4.5 mmol) and K2CO3 in ethanol (4 ml) was heated to 60° C. for 24 h. Then the solvent was removed under vacuum at 40° C. The residue was taken up in ether and the solvent evaporated to yield 0.52 g (57%) of a highly viscous oil as a mixture of diastereoisomers.
後処理
- customThen the solvent was removed under vacuum at 40° C
- customthe solvent evaporated
- customto yield 0.52 g (57%) of a highly viscous oil
- additionas a mixture of diastereoisomers
出典と根拠
- ORDレコード
- ord-625699e9e27741c5be5c208f1d623f40
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399499B2
反応ノート
読み込み中…