HCID 68841469、化合物 → HCID 68694413、化合物
反応式
Cl.[CH2:2]([C:4]1([N:14]([CH3:16])[CH3:15])[CH2:13][CH2:12][C:7]2(OCC[O:8]2)[CH2:6][CH2:5]1)[CH3:3]>Cl>[CH3:15][N:14]([CH3:16])[C:4]1([CH2:2][CH3:3])[CH2:13][CH2:12][C:7](=[O:8])[CH2:6][CH2:5]1参加物
3
実験手順
(8-ethyl-1,4-dioxa-spiro[4.5]dec-8-yl)-dimethylamine hydrochloride (6.67 g, 0.026 mmole) was dissolved in 6N HCl (40 ml) and stirred overnight at room temperature. The reaction mixture was extracted twice with diethyl ether (100 ml). The reaction mixture was then made alkaline with 5N NaOH while cooling with ice and extracted a further three times with Et2O (100 ml). The combined organic phases were dried over Na2SO4, filtered, and the solvent was removed in vacuo.
後処理
- extractionThe reaction mixture was extracted twice with diethyl ether (100 ml)
- temperaturewhile cooling with ice
- extractionextracted a further three times with Et2O (100 ml)
- dry with materialThe combined organic phases were dried over Na2SO4
- filtrationfiltered
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-445d560e766b4c92bbfad8705a355321
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08399503B2
反応ノート
読み込み中…