3-{[1-(4-Oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl ester → 3-[(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester

HRID 1949479

反応式

HRID 1949479 の反応式
[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH2:12][N:11]([C:13]2[S:14][CH2:15][C:16](=[O:18])[N:17]=2)[CH2:10]1)=[O:8].[Cl:20][C:21]1[CH:38]=[CH:37][C:24]([CH2:25][N:26]2[C:34]3[C:29](=[CH:30][C:31]([CH:35]=O)=[CH:32][CH:33]=3)[CH:28]=[N:27]2)=[C:23]([C:39]([F:42])([F:41])[F:40])[CH:22]=1>>[CH3:1][O:2][C:3](=[O:19])[CH2:4][CH2:5][NH:6][C:7]([CH:9]1[CH2:10][N:11]([C:13]2[S:14][C:15](=[CH:35][C:31]3[CH:30]=[C:29]4[C:34](=[CH:33][CH:32]=3)[N:26]([CH2:25][C:24]3[CH:37]=[CH:38][C:21]([Cl:20])=[CH:22][C:23]=3[C:39]([F:42])([F:40])[F:41])[N:27]=[CH:28]4)[C:16](=[O:18])[N:17]=2)[CH2:12]1)=[O:8]

参加物

3

反応物 2

HCID 672398093-{[1-(4-Oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl esterHCID 866545471-(4-chloro-2-(trifluoromethyl)benzyl)-1H-indazole-5-carbaldehyde

生成物 1

HCID 672410533-[(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester

実験手順

3-[(1-{5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-4-oxo-4,5-dihydro-thiazol-2-yl}-azetidine-3-carbonyl)-amino]-propionic acid methyl ester was prepared from 3-{[1-(4-oxo-4,5-dihydro-thiazol-2-yl)-azetidine-3-carbonyl]-amino}-propionic acid methyl ester and 1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazole-5-carbaldehyde following General Procedure D.

出典と根拠

ORDレコード
ord-76bf89bf9fc140648c2eaee487c963f2
出典データセット
uspto-grants-2013_03
特許番号
US08399681B2

関連ノート

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