4-Piperidinecarboxylic acid → 1-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid

HRID 1949500

反応式

HRID 1949500 の反応式
CS[C:3]1[S:4][CH2:5][C:6](=[O:8])[N:7]=1.[NH:9]1[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1>CO>[O:8]=[C:6]1[CH2:5][S:4][C:3]([N:9]2[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]2)=[N:7]1

参加物

4

反応物 2

HCID 37734-Piperidinecarboxylic acidHCID 14820222-(Methylsulfanyl)-4,5-dihydro-1,3-thiazol-4-one

生成物 1

HCID 672406401-(4-Oxo-4,5-dihydro-thiazol-2-yl)piperidine-4-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-methylsulfanyl-thiazol-4-one (4.4 g, 30 mmol) in MeOH (60 mL) was added piperidine-4-carboxylic acid (3.9 g, 30 mmol). The mixture was stirred at room temperature for 16 hours. The resulting solid was collected by filtration, washed with fresh MeOH and dried to give the title compound.

後処理

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with fresh MeOH
  3. customdried

出典と根拠

ORDレコード
ord-72f7a526c84c4e3faa7d653322bc5d49
出典データセット
uspto-grants-2013_03
特許番号
US08399681B2

関連ノート

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