4-Fluorobenzonitrile → 4-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzaldehyde

HRID 1949995ノート

反応式

HRID 1949995 の反応式
N12CCC(C[OH:10])(CC1)CC2.FC1C=CC(C#N)=CC=1.[N:20]12[CH2:27][CH2:26][C:23]([CH2:28][O:29][C:30]3[CH:37]=[CH:36][C:33]([C:34]#N)=[CH:32][CH:31]=3)([CH2:24][CH2:25]1)[CH2:22][CH2:21]2>>[N:20]12[CH2:27][CH2:26][C:23]([CH2:28][O:29][C:30]3[CH:37]=[CH:36][C:33]([CH:34]=[O:10])=[CH:32][CH:31]=3)([CH2:24][CH2:25]1)[CH2:22][CH2:21]2

参加物

4

反応物 3

HCID 145174-FluorobenzonitrileHCID 1413111-Azabicyclo(2.2.2)octane-4-methanolHCID 666269004-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzonitrile

生成物 1

HCID 579343134-(1-Azabicyclo[2.2.2]oct-4-ylmethoxy)benzaldehyde

実験手順

Synthesized from (1-azabicyclo[2.2.2]oct-4-yl)methanol and 4-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 4-(1-azabicyclo[2.2.2]oct-4-ylmethoxy)benzonitrile (200 mg) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (120 mg).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 16

出典と根拠

ORDレコード
ord-56844cfe624a4eb0a8246201ab341126
出典データセット
uspto-grants-2013_03
特許番号
US08399520B2

反応ノート

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