4-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrile → 4-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

HRID 1949998ノート

反応式

HRID 1949998 の反応式
NC(C)(C)C[O:4]C1C=CC(C#N)=CC=1F.[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([C:25]#N)=[CH:23][C:22]=1[F:29]>>[CH3:16][N:17]([CH3:32])[C:18]([CH3:31])([CH3:30])[CH2:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH:25]=[O:4])=[CH:23][C:22]=1[F:29]

参加物

3

反応物 2

HCID 230872344-(2-Amino-2-methylpropoxy)-3-fluorobenzonitrileHCID 230874174-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile

生成物 1

HCID 230871524-(2-Dimethylamino-2-methylpropoxy)-3-fluorobenzaldehyde

実験手順

Synthezised from 4-(2-amino-2-methylpropoxy)-3-fluorobenzonitrile according to an analogous synthetic method to Preparation Example 18, 4-(2-dimethylamino-2-methylpropoxy)-3-fluorobenzonitrile (1.4 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (965 mg).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 16

出典と根拠

ORDレコード
ord-e6cd3bba8fad4beb9fa314f7bd755977
出典データセット
uspto-grants-2013_03
特許番号
US08399520B2

反応ノート

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