Cyclopropylamine → [6-(2-Chloro-imidazol-1-yl)-pyrimidin-4-yl]-cyclopropyl-amine

HRID 19500ノート

反応式

HRID 19500 の反応式
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH:12]=[CH:11][N:10]=[C:9]2[Cl:13])[N:5]=[CH:4][N:3]=1.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>CO>[Cl:13][C:9]1[N:8]([C:6]2[N:5]=[CH:4][N:3]=[C:2]([NH:17][CH:14]3[CH2:16][CH2:15]3)[CH:7]=2)[CH:12]=[CH:11][N:10]=1

参加物

4

反応物 2

HCID 69828CyclopropylamineHCID 589730674-Chloro-6-(2-chloro-imidazol-1-yl)-pyrimidine

生成物 1

HCID 58973138[6-(2-Chloro-imidazol-1-yl)-pyrimidin-4-yl]-cyclopropyl-amine収率 90%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
50 °C

実験手順

4-Chloro-6-(2-chloro-imidazol-1-yl)-pyrimidine (0.85 g, 4 mmol) and cyclopropylamine (1.4 mL, 20 mmol) were mixed in 10 mL methanol and stirred at 50° C. for 12 hours. After reaction was complete, the solvent was removed by rotary evaporation. The crude product was washed with water and taken to dryness to give the title compound (0.84 g, 90%); 1H NMR 400 MHz (DMSO-d6) δ 8.45 (s, 1H), 8.17 (d, 1H), 7.75 (s, 1 H), 7.08 (s, 1H), 6.80 (d, 1H), 3.34 (s, 1H), 0.78 (br, 2H), 0.52 (br, 2H); MS m/z 236.4 (M+1).

後処理

  1. customAfter reaction
  2. customthe solvent was removed by rotary evaporation
  3. washThe crude product was washed with water

出典と根拠

ORDレコード
ord-7639acae788645ac9f0a1c2194593ae7
出典データセット
uspto-grants-2010_06
特許番号
US07745437B2

反応ノート

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