4-Piperidinol, 1-methyl- → HCID 23087228、化合物

HRID 1950001ノート

反応式

HRID 1950001 の反応式
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

参加物

4

反応物 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

生成物 1

HCID 23087228HCID 23087228、化合物

実験手順

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

後処理

  1. customwas used according to an analogous synthetic method to Preparation Example 16

出典と根拠

ORDレコード
ord-5180b8cb5d5d4ddfaf4ff088581d6be1
出典データセット
uspto-grants-2013_03
特許番号
US08399520B2

反応ノート

読み込み中…