Water → 5-(Benzyloxy)pyridine-2-carboxylic acid

HRID 1950009ノート

反応式

HRID 1950009 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]=[O:16])=[N:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.S(=O)(=O)([OH:20])N.Cl([O-])=O.[Na+]>CC(C)=O>[CH2:1]([O:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]([OH:20])=[O:16])=[N:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 5987Sulfamic AcidHCID 123972545-(Benzyloxy)pyridine-2-carbaldehydeHCID 23668197Sodium Chlorite

生成物 1

HCID 183793525-(Benzyloxy)pyridine-2-carboxylic acid収率 73.4%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 5-benzyloxypyridine-2-carbaldehyde (3.8 g) in acetone (50 ml) was added water (50 ml), sulfamic acid (2.4 g) and sodium chlorite (2.2 g) were sequentially added thereto on an ice bath, and the solution was stirred for 6 hours at room temperature. The solid that was precipitated was filtered and rinsed with water to provide the title compound (3.0 g).

後処理

  1. additionwere sequentially added
  2. customThe solid that was precipitated
  3. filtrationwas filtered
  4. washrinsed with water

出典と根拠

ORDレコード
ord-89d035fca62745bca76173e20e6a7228
出典データセット
uspto-grants-2013_03
特許番号
US08399520B2

反応ノート

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