2-chloro-N-(2-methoxyethyl)-N-methylacetamide → 6-{4-Methoxy-2-{{4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl}methylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol

HRID 1950422ノート

反応式

HRID 1950422 の反応式
[OH:1][C:2]1[CH:36]=[CH:35][C:5]([C:6]([CH2:8][NH:9][C:10]2[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:11]=2[CH:18]2[CH2:27][CH2:26][C:25]3[CH:24]=[C:23]([O:28]C(=O)C(C)(C)C)[CH:22]=[CH:21][C:20]=3[CH2:19]2)=O)=[CH:4][CH:3]=1.Cl[CH2:38][C:39]([N:41]([CH2:43][CH2:44][O:45][CH3:46])[CH3:42])=O>>[CH3:17][O:16][C:14]1[CH:13]=[CH:12][C:11]([CH:18]2[CH2:27][CH2:26][C:25]3[CH:24]=[C:23]([OH:28])[CH:22]=[CH:21][C:20]=3[CH2:19]2)=[C:10]([NH:9][CH2:8][CH2:6][C:5]2[CH:35]=[CH:36][C:2]([O:1][CH2:38][CH2:39][N:41]([CH2:43][CH2:44][O:45][CH3:46])[CH3:42])=[CH:3][CH:4]=2)[CH:15]=1

参加物

3

反応物 2

HCID 151749132-chloro-N-(2-methoxyethyl)-N-methylacetamideHCID 66626427Pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester

生成物 1

HCID 666266316-{4-Methoxy-2-{{4-{2-[(2-methoxyethyl)methylamino]ethoxy}benzyl}methylamino}phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol収率 50.2%

実験手順

Synthesized from pivalic acid 6-{2-[(4-hydroxybenzoyl)methylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 2-chloro-N-(2-methoxyethyl)-N-methylacetamide (16 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (13 mg) was obtained.

後処理

  1. custompurified by LC-MS

出典と根拠

ORDレコード
ord-461778f4982f4addbe77976555abe656
出典データセット
uspto-grants-2013_03
特許番号
US08399520B2

反応ノート

読み込み中…