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2-chloro-N-(2-methoxyethyl)acetamide → 6-{2-{Ethyl {4-[2-(2-methoxyethylamino)ethoxy]benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-chloro-N-(2-methoxyethyl)acetamide | HCID 2386048 | — |
| 反応物 | Pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester | HCID 57934562 | — |
| 生成物 | 6-{2-{Ethyl {4-[2-(2-methoxyethylamino)ethoxy]benzyl}amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol | HCID 58023083 | 13.9% |
反応手順
Synthesized from pivalic acid 6-{2-[ethyl(4-hydroxybenzoyl)amino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (25 mg) and 2-chloro-N-(2-methoxyethyl)acetamide (14 mg) according to an analogous synthetic method to Example 567 and purified by LC-MS, the title compound (3.5 mg) was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08399520B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-f8dd7c0536fa41d8b63252ef0bc2bf73 |
| 出典メモ | uspto-grants-2013_03 |