1-(Azepan-1-yl)-2-chloroethan-1-one → (R)-6-{2-{[4-(2-Azepan-1-ylethoxy)-3-fluorobenzyl]isopropylamino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:36]=[CH:37][C:38]=1[OH:39])[C:5]([N:7]([CH:33]([CH3:35])[CH3:34])[C:8]1[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=1[C@@H:16]1[CH2:25][CH2:24][C:23]2[CH:22]=[C:21]([O:26]C(=O)C(C)(C)C)[CH:20]=[CH:19][C:18]=2[CH2:17]1)=O.[N:40]1([C:47](=O)[CH2:48]Cl)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1>>[N:40]1([CH2:47][CH2:48][O:39][C:38]2[CH:37]=[CH:36][C:4]([CH2:5][N:7]([CH:33]([CH3:35])[CH3:34])[C:8]3[CH:13]=[C:12]([O:14][CH3:15])[CH:11]=[CH:10][C:9]=3[C@@H:16]3[CH2:17][CH2:18][C:23]4[CH:22]=[C:21]([OH:26])[CH:20]=[CH:19][C:24]=4[CH2:25]3)=[CH:3][C:2]=2[F:1])[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42][CH2:41]1参加物
3
反応物 2
生成物 1
実験手順
Synthesized from pivalic acid (R)-6-{2-[(3-fluoro-4-hydroxybenzoyl)isopropylamino]-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-yl ester (19 mg) and 1-azepan-1-yl-2-chloroethanone (12 mg) according to an analogous synthetic method to Example 404 and purified by LC-MS, the title compound (5.0 mg) was obtained.