Hydroxylamine → N'-hydroxy-2-(trifluoromethoxy)benzenecarboximidamide
反応式
[NH2:1][OH:2].[F:3][C:4]([F:15])([F:14])[O:5][C:6]1[CH:13]=[CH:12][CH:11]=[CH:10][C:7]=1[C:8]#[N:9]>CCO>[OH:2][N:1]=[C:8]([C:7]1[CH:10]=[CH:11][CH:12]=[CH:13][C:6]=1[O:5][C:4]([F:3])([F:14])[F:15])[NH2:9]参加物
4
反応条件
- 温度
- 60 °C
実験手順
Hydroxylamine (Fluka 55458; 50% in water; 4.81 mL; 80.16 mmol; 5 eq.) was added to a solution of 2-(trifluoromethoxy)benzonitrile (Apollo PC7438E; 3 g; 16.03 mmol; 1 eq.) in EtOH (20 mL) and the reaction mixture was stirred at 60° C. for 10 hours. Evaporation in vacuo gave a white solid, which was further dried under high vacuum to afford the title compound (3.30 g, 94%) as a white solid.
後処理
- customEvaporation in vacuo
- customgave a white solid, which
- customwas further dried under high vacuum
出典と根拠
- ORDレコード
- ord-eb14528756814f28aae1d52e4334444f
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08404676B2
反応ノート
読み込み中…