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Oxalyl chloride → N,N-bis(2-methoxyethyl)-4-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-nitroaniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | N-Hydroxy-2-methoxy-benzamidine | HCID 4652214 | — |
| 反応物 | 4-[Bis(2-methoxyethyl)amino]-3-nitrobenzoic acid | HCID 59606538 | — |
| 生成物 | N,N-bis(2-methoxyethyl)-4-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-2-nitroaniline | HCID 25256655 | — |
反応手順
Oxalyl chloride (190 mg; 1.5 mmol; 3 eq.), Intermediate 31 (149 mg; 0.5 mmol; 1 eq.), Intermediate 1 (83 mg; 0.5 mmol, 1 eq.) and DIEA (194 mg; 1.5 mmol; 3 eq.) were reacted according to general procedure 2. Purification by column chromatography (c-hexane/ethyl acetate, 50/50) followed by crystallisation from Et2O/n-pentane afforded the title compound as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08404676B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-ba0ad6ea84d44d6ea25f84d87fa26d2e |
| 出典メモ | uspto-grants-2013_03 |