Hydrochloric Acid → cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride

HRID 1950896

反応式

HRID 1950896 の反応式
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([C@H:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@H:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 66680888cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester

生成物 1

HCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride収率 85%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester (1.8 g, 6.7 mmol) was dissolved in dioxane. 4H HCl in dioxane (17 mL, 67 mmol) were added and the reaction mixture was stirred at room temperature overnight. The solvent was evaporated off. The residue was crystallized with ethanol and yielded cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride as a white solid (1.37 g, 85%), MS: m/e=169.2 [(M+H)+].

後処理

  1. customThe solvent was evaporated off
  2. customThe residue was crystallized with ethanol

出典と根拠

ORDレコード
ord-826d66ca1440479b9ffe73346e50cb50
出典データセット
uspto-grants-2013_03
特許番号
US08404673B2

関連ノート

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