1,4-Dibromo-2-butanol → cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

HRID 1950950

反応式

HRID 1950950 の反応式
[NH2:1][C@H:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:24])[C:10]1[C:15]([S:16][CH3:17])=[CH:14][C:13]([C:18]([F:21])([F:20])[F:19])=[CH:12][C:11]=1[O:22][CH3:23].Br[CH2:26][CH:27]([OH:31])[CH2:28][CH2:29]Br>>[OH:31][CH:27]1[CH2:28][CH2:29][N:1]([C@H:2]2[CH2:7][CH2:6][CH2:5][CH2:4][C@H:3]2[NH:8][C:9](=[O:24])[C:10]2[C:15]([S:16][CH3:17])=[CH:14][C:13]([C:18]([F:20])([F:21])[F:19])=[CH:12][C:11]=2[O:22][CH3:23])[CH2:26]1

参加物

3

反応物 2

HCID 295701,4-Dibromo-2-butanolHCID 58062914cis-N-(2-Amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide2 回

生成物 1

HCID 58062933cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide

実験手順

The title compound, light yellow foam, MS: m/e=433.2 [(M+H)+], was prepared in accordance with the general method of example 10 from cis-N-(2-amino-cyclohexyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate I) and 1,4-dibromo-2-butanol. The two diastereomers were not separated.

出典と根拠

ORDレコード
ord-1df2402ed0fc418196bddc1714b2788e
出典データセット
uspto-grants-2013_03
特許番号
US08404673B2

関連ノート

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