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(Bis(2-methoxyethyl)amino)sulfur trifluoride → cis-N-[2-(3-Fluoro-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Bis(2-methoxyethyl)amino)sulfur trifluoride | HCID 2734690 | — |
| 反応物 | cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide | HCID 58062933 | — |
| 生成物 | cis-N-[2-(3-Fluoro-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide | HCID 58062851 | — |
反応手順
The title compound, light yellow solid, MS: m/e=435.3 [(M+H)+], was prepared in accordance with the general method of example 17 from cis-N-[2-(3-Hydroxy-pyrrolidin-1-yl)-cyclohexyl]-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (example 24) and bis(2-methoxyethyl)aminosulfur trifluoride. The two diastereomers were not separated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08404673B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-eceaa5a7268a465c978db29e54a34fbe |
| 出典メモ | uspto-grants-2013_03 |