Dimethylamine → N-((1RS,2SR)-2-Dimethylamino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide
反応式
[CH3:1][O:2][C:3]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[C:14]([S:22][CH3:23])[C:4]=1[C:5]([NH:7][CH:8]1[CH2:12][CH2:11][CH2:10][C:9]1=O)=[O:6].[CH3:24][NH:25][CH3:26]>>[CH3:24][N:25]([CH3:26])[CH:9]1[CH2:10][CH2:11][CH2:12][CH:8]1[NH:7][C:5](=[O:6])[C:4]1[C:14]([S:22][CH3:23])=[CH:15][C:16]([C:18]([F:21])([F:20])[F:19])=[CH:17][C:3]=1[O:2][CH3:1]参加物
3
実験手順
The title compound, brown gum, MS: m/e=377.3 [(M+H, was prepared in accordance with the general method of example 1 and 2 from 2-methoxy-6-methylsulfanyl-N-(2-oxo-cyclopentyl)-4-trifluoromethyl-benzamide (intermediate M) and dimethylamine. The cis- and trans-isomer could be separated by column chromatography.
出典と根拠
- ORDレコード
- ord-72f8cb3f6ccd44cb88ed423a5314138a
- 出典データセット
- uspto-grants-2013_03