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2,4-Bis(trifluoromethyl)benzamide → 2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,4-Bis(trifluoromethyl)benzamide | HCID 2736099 | — |
| 反応物 | 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide | HCID 11097568 | — |
| 反応物 | N-((1RS,2SR)-2-Amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide | HCID 66681196 | — |
| 生成物 | 2-Methoxy-6-methylsulfanyl-N-[(1RS,2SR)-2-(4-oxo-piperidin-1-yl)-cyclopentyl]-4-trifluoromethyl-benzamide | HCID 66681255 | — |
反応手順
The title compound, yellow gum, MS: m/e=431.3 [(M+H)+], was prepared in accordance with the general method of intermediate J from N-((1RS, 2SR)-2-amino-cyclopentyl)-2-methoxy-6-methylsulfanyl-4-trifluoromethyl-benzamide (intermediate O) and 1-ethyl-1-methyl-4-oxo-piperidinium iodide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08404673B2 |
| 出典データセット | uspto-grants-2013_03 |
| ORD ID | ord-d4524e3201a347c1884c1f547c0114f7 |
| 出典メモ | uspto-grants-2013_03 |