cis-2-Pyrrolidin-1-yl-cyclopentylamine → 2-Ethyl-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

HRID 1951013ノート

反応式

HRID 1951013 の反応式
[N:1]1([C@H:6]2[CH2:10][CH2:9][CH2:8][C@H:7]2[NH2:11])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:12]([C:14]1[CH:22]=[C:21]([C:23]([F:26])([F:25])[F:24])[CH:20]=[C:19]([C:27]([F:30])([F:29])[F:28])[C:15]=1[C:16](O)=[O:17])[CH3:13]>>[CH2:12]([C:14]1[CH:22]=[C:21]([C:23]([F:25])([F:26])[F:24])[CH:20]=[C:19]([C:27]([F:28])([F:29])[F:30])[C:15]=1[C:16]([NH:11][C@@H:7]1[CH2:8][CH2:9][CH2:10][C@@H:6]1[N:1]1[CH2:2][CH2:3][CH2:4][CH2:5]1)=[O:17])[CH3:13]

参加物

3

反応物 2

HCID 30820884cis-2-Pyrrolidin-1-yl-cyclopentylamine2 回HCID 591979342-Ethyl-4,6-bis-trifluoromethyl-benzoic acid

生成物 1

HCID 510013292-Ethyl-N-((cis)-2-pyrrolidin-1-yl-cyclopentyl)-4,6-bis-trifluoromethyl-benzamide

実験手順

The title compound, white solid, MS: m/e=423.3 [(M+H)+], was prepared in accordance with the general method of example 5 from cis-2-pyrrolidin-1-yl-cyclopentylamine (intermediate Q) and 2-ethyl-4,6-bis-trifluoromethyl-benzoic acid (intermediate AO).

出典と根拠

ORDレコード
ord-e5b7ef4f3a8e445ca0e6ad17d64d0961
出典データセット
uspto-grants-2013_03
特許番号
US08404673B2

反応ノート

読み込み中…