Sodium Methoxide → 5-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-ylamine

HRID 1951187ノート

反応式

HRID 1951187 の反応式
Br.[CH3:2][C:3]1[CH:8]=[C:7]([C:9]2[S:13][C:12]([NH2:14])=[N:11][C:10]=2[CH3:15])[CH:6]=[C:5]([CH3:16])[N:4]=1.C[O-].[Na+]>CO>[CH3:2][C:3]1[CH:8]=[C:7]([C:9]2[S:13][C:12]([NH2:14])=[N:11][C:10]=2[CH3:15])[CH:6]=[C:5]([CH3:16])[N:4]=1

参加物

4

反応物 2

HCID 10942334Sodium MethoxideHCID 866103325-(2,6-Dimethyl-pyridin-4-yl)4-methyl-thiazol-2-ylamine hydrobromide

生成物 1

HCID 450976375-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-ylamine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

実験手順

To a stirred solution of 5-(2,6-Dimethyl-pyridin-4-yl)-4-methyl-thiazol-2-ylamine hydrobromide (3.29 g, 11 mmol) in methanol (30 ml) is added sodium methoxide (2 ml of a 30% solution in methanol, 11 mmol). The resulting mixture is filtered through Celite™ filter material and concentrated in vacuo to yield the titled compound.

後処理

  1. filtrationThe resulting mixture is filtered through Celite™
  2. filtrationfilter material
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-53d76a972a314913863a7893bfa6fb95
出典データセット
uspto-grants-2013_03
特許番号
US08404684B2

反応ノート

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