Dimethylformamide → 5-(4-Chlorophenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)furan-2-carboxamide

HRID 1951252

反応式

HRID 1951252 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][C:11]([C:13]([OH:15])=O)=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl.[NH2:17][C:18]1[CH:19]=[C:20]([CH:27]=[CH:28][C:29]=1[CH3:30])[C:21]([NH:23][CH:24]1[CH2:26][CH2:25]1)=[O:22].CN(C=O)C>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[O:12][C:11]([C:13]([NH:17][C:18]3[CH:19]=[C:20]([C:21](=[O:22])[NH:23][CH:24]4[CH2:26][CH2:25]4)[CH:27]=[CH:28][C:29]=3[CH3:30])=[O:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 7266935-(4-Chlorophenyl)-2-furoic acidHCID 442031943-Amino-N-cyclopropyl-4-methylbenzamide hydrochloride

生成物 1

HCID 597613905-(4-Chlorophenyl)-N-(5-(cyclopropylcarbamoyl)-2-methylphenyl)furan-2-carboxamide収率 98.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 5-(4-chlorophenyl)furan-2-carboxylic acid (45 mg, 0.20 mmol) and 3-amino-N-cyclopropyl-4-methylbenzamide hydrochloride (prepared as described in WO 04/071440) (50 mg, 0.22 mmol) in DMF (0.5 mL) DIPEA (0.105 mL, 0.6 mmol) and the resulting mixture was stirred at rt for 1 h then at 80° C. for 1 h. The reaction was cooled to rt and water (3 mL) was added and the crude product was collected by vacuum filtration and dried under vacuum to afford 78 mg of a tan solid. The crude product was recrystallized from CH2Cl2 to afford 48 mg of a light tan solid as the title compound (Example 127). HPLC Ret. Time=3.52 min, LCMS [M+H]+ 395.23.

後処理

  1. filtrationthe crude product was collected by vacuum filtration
  2. customdried under vacuum

出典と根拠

ORDレコード
ord-40f064ff8fea4e9cbb3a914b6939ab0e
出典データセット
uspto-grants-2013_03
特許番号
US08404689B2

関連ノート

読み込み中…