3-cyclopropyl-1H-pyrazol-5-amine → HCID 178516372、化合物

反応式

[CH:1]1([C:4]2[NH:8][N:7]=[C:6]([NH2:9])[CH:5]=2)[CH2:3][CH2:2]1.C([O:12][C:13](=O)/[CH:14]=[CH:15]\[O-])C.[Na+]>CCO.C1(C)C=CC=CC=1>[CH:1]1([C:4]2[CH:5]=[C:6]3[N:9]=[CH:15][CH:14]=[C:13]([OH:12])[N:7]3[N:8]=2)[CH2:3][CH2:2]1

参加物

反応条件

温度: 80 °C

実験手順

A mixture of 5-cyclopropyl-1H-pyrazol-3-amine (415 mg, 3.37 mmol) and sodium (Z)-3-ethoxy-3-oxoprop-1-en-1-olate (0.791 g, 5.73 mmol) in EtOH (3 mL) and toluene (1 mL) was heated to 80° C. in a resealable tube. After 16 hrs the solvent was removed in vacuo. The resulting residue was dissolved in a minimal amount of warm water and triturated with 1 N HCl with cooling (0° C.) until the pH ˜1. The resulting solid was filtered and washed with water to afford 2-cyclopropylpyrazolo[1,5-a]pyrimidin-7-ol as an off-white solid that was advanced without further purification. M+H+ found=176.2.