Potassium Hydroxide → 1-Amino-1H-pyrrole-2-carboxamide
反応式
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]#[N:8].[OH-:9].[K+]>O>[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:8])=[O:9]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution of 1-amino-1H-pyrrole-2-carbonitrile (100 mg, 0.934 mmol) and potassium hydroxide (1.26 g, 22.5 mmol) in water (3 mL) was stirred at RT for 6 hours. The resulting mixture was then cooled to 0° C. and filtered. The collected solid was washed with cold water until the washings were pH neutral and purified by silica gel chromatography using 0-100% of 90/10/1 CH2Cl2/MeOH/NH4OH in CH2Cl2 to afford 1-amino-1H-pyrrole-2-carboxamide.
後処理
- filtrationfiltered
- washThe collected solid was washed with cold water until the washings
- custompurified by silica gel chromatography
出典と根拠
- ORDレコード
- ord-75e8d57a84ed476ea5fc27c126e1ce74
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08404694B2
反応ノート
読み込み中…