Formic Acid → 1-(Formylamino)-1H-pyrrole-2-carboxamide
反応式
[NH2:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:9])=[O:8].[C:10]([O-])(=[O:12])C.[Na+].C(O)=O>>[CH:10]([NH:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([NH2:9])=[O:8])=[O:12]参加物
4
実験手順
To a mixture of 1-Amino-1H-pyrrole-2-carboxamide (1.00 g, 8.0 mmol) and sodium acetate (1.60 g, 20.0 mmol) was added formic acid (11.0 ml, 287 mmol). The mixture was stirred overnight at RT. After removing the excess formic acid in vacuo, water (5 mL) was added and the mixture was cooled to 0° C. The mixture was filtered and the solid washed with water and dried in vacuo to afford 1-formamido-1H-pyrrole-2-carboxamide which was advanced without further purification.
後処理
- customAfter removing the excess formic acid in vacuo, water (5 mL)
- additionwas added
- temperaturethe mixture was cooled to 0° C
- filtrationThe mixture was filtered
- washthe solid washed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-fbb94cc2f08b4116ad22d3202488767c
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08404694B2
反応ノート
読み込み中…