4-(2-Acetyl-3-oxo-1-butenyl)benzonitrile → HCID 59603008、化合物

HRID 1951378

反応式

HRID 1951378 の反応式
[C:1]([C:4]([C:14](=[O:16])[CH3:15])=[CH:5][C:6]1[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=1)(=O)[CH3:2].[NH2:17][C:18]1[CH:23]=[CH:22][NH:21][C:20](=[O:24])[CH:19]=1>C(O)(C)C>[C:14]([C:4]1[CH:5]([C:6]2[CH:13]=[CH:12][C:9]([C:10]#[N:11])=[CH:8][CH:7]=2)[C:19]2[C:20](=[O:24])[NH:21][CH:22]=[CH:23][C:18]=2[NH:17][C:1]=1[CH3:2])(=[O:16])[CH3:15]

参加物

4

反応物 2

HCID 3674534-(2-Acetyl-3-oxo-1-butenyl)benzonitrileHCID 5735304-Amino-1,2-dihydropyridin-2-one

生成物 1

HCID 59603008HCID 59603008、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

1.5 g (7.04 mmol) of 4-(2-acetyl-3-oxobut-1-en-1-yl)benzonitrile are mixed with 0.77 g (7.04 mmol) of 4-aminopyridin-2(1H)-one [Searls, T., McLaughlin, L. W., Tetrahedron 55, 11985-11996 (1999)], dissolved in 40 ml of isopropanol and heated under reflux under argon for 4 days. The mixture is then concentrated and the residue is recrystallized from methanol. 0.67 g (31% of theory) of the title compound is obtained as a pale yellow solid.

後処理

  1. temperatureheated
  2. temperatureunder reflux under argon for 4 days
  3. concentrationThe mixture is then concentrated
  4. customthe residue is recrystallized from methanol

出典と根拠

ORDレコード
ord-e7fa23e6a6f34308b291a4bbc8dcc447
出典データセット
uspto-grants-2013_03
特許番号
US08404709B2

関連ノート

読み込み中…