Aniline → 6-(dimethylamino)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

HRID 1952200

反応式

HRID 1952200 の反応式
C[Al](C)C.[NH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[CH3:12][N:13]([CH3:28])[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([CH:20]=[C:21]([C:23](OCC)=[O:24])[N:22]=2)[CH:19]=1.[Cl-].[NH4+]>C1(C)C=CC=CC=1>[CH3:12][N:13]([CH3:28])[C:14]1[CH:15]=[CH:16][C:17]2[N:18]([CH:20]=[C:21]([C:23]([NH:5][C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=3)=[O:24])[N:22]=2)[CH:19]=1

参加物

6

反応物 4

HCID 6115AnilineHCID 25517Ammonium ChlorideHCID 16682925TrimethylaluminumHCID 44124134Ethyl 6-dimethylaminoimidazo[1,2-a]pyridine-2-carboxylate

生成物 1

HCID 247716096-(dimethylamino)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

0.46 ml of a 2M solution of trimethylaluminum in toluene is added dropwise to a solution, cooled to 0° C., of 60.8 μl of aniline in 3 ml of toluene, followed, at 20° C., by the addition of 76 mg of ethyl 6-dimethylaminoimidazo[1,2-a]pyridine-2-carboxylate. The reaction mixture is stirred at ambient temperature for 15 minutes. It is cooled to 0° C. and then 20 ml of a saturated ammonium chloride solution are added. The organic phase is dried over magnesium sulfate, filtered through Celite and evaporated to dryness under reduced pressure. The residue is chromatographed on a silica cartridge, elution being carried out with a mixture of dichloromethane and ethyl acetate. The fractions comprising the product are combined and concentrated to dryness under reduced pressure. The residue obtained is crystallized from methanol to give 36 mg of 6-(dimethylamino)-N-phenylimidazo[1,2-a]pyridine-2-carboxamide in the form of a gray powder.

後処理

  1. temperatureIt is cooled to 0° C.
  2. dry with materialThe organic phase is dried over magnesium sulfate
  3. filtrationfiltered through Celite
  4. customevaporated to dryness under reduced pressure
  5. customThe residue is chromatographed on a silica cartridge, elution
  6. additionbeing carried out with a mixture of dichloromethane and ethyl acetate
  7. concentrationconcentrated to dryness under reduced pressure
  8. customThe residue obtained
  9. customis crystallized from methanol

出典と根拠

ORDレコード
ord-c62d9bb4571c456b832ee3039678223c
出典データセット
uspto-grants-2013_03
特許番号
US08404848B2

関連ノート

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