関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | 2-(3-Methoxy-benzyl)-3-oxo-3-phenyl-propionic acid ethyl ester | HCID 11844953 | — |
| 反応物 | HCID 178478979 | HCID 178478979 | — |
| 生成物 | 1-hydroxy-6-methoxy-1,3-diphenyl-1H-indene-2-carboxylic acid ethyl ester | HCID 11596168 | 76% |
反応手順
The compound (300 mg, 0.97 mmol) obtained in Step 1 was dissolved in THF and 1.5 equivalents of phenylmagnesium chloride were added thereto, followed by stirring for 1 hr at 0° C. Then, the resulting mixture washed with saturated saline, and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 285 mg of the titled compound (yield: 76%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07745439B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-6752d39a677c4ee1b9821a25bdb58aaf |
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| 出典メモ | uspto-grants-2010_06 |
|---|
