Methanol → HCID 178499647、化合物
反応式
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][C:11]([OH:13])=[O:12])=[N:2]1.[CH3:14]O>Cl>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH2:10][C:11]([O:13][CH3:14])=[O:12])=[N:2]1参加物
4
実験手順
To a solution of 1H-pyrazolo[3,4-b]pyridin-3-ylacetic acid (92 mg, 0.520 mmol) in methanol (4 mL) was bubbled in HCl gas for 2 minutes and the resulting solution was allowed to stand for a further 10 minutes. After this time, the solution was concentrated in vacuo and the resulting residue was partitioned between aqueous NaHCO3 (10 mL) and ethyl acetate (2×10 mL). The combined organic extracts were washed with brine, dried over MgSO4, filtered and the solvent evaporated in vacuo to provide the title compound. LRMS (M+1): 192.0.
後処理
- concentrationAfter this time, the solution was concentrated in vacuo
- customthe resulting residue was partitioned between aqueous NaHCO3 (10 mL) and ethyl acetate (2×10 mL)
- washThe combined organic extracts were washed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customthe solvent evaporated in vacuo
出典と根拠
- ORDレコード
- ord-77d3ff586e91461981571b5880fd712e
- 出典データセット
- uspto-grants-2013_03
- 特許番号
- US08404856B2
反応ノート
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