Triethyl phosphite → HCID 15272444、化合物

HRID 1952418ノート

反応式

HRID 1952418 の反応式
[F:1][C:2](Br)([F:14])[C:3]1[C:8]([F:9])=[C:7]([F:10])[C:6]([F:11])=[C:5]([F:12])[C:4]=1[F:13].[P:16]([O:23]CC)([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19]>O1CCOCC1>[F:1][C:2]([F:14])([P:16](=[O:23])([O:20][CH2:21][CH3:22])[O:17][CH2:18][CH3:19])[C:3]1[C:8]([F:9])=[C:7]([F:10])[C:6]([F:11])=[C:5]([F:12])[C:4]=1[F:13]

参加物

4

反応物 2

HCID 31215Triethyl phosphiteHCID 218642771-[Bromo(difluoro)methyl]-2,3,4,5,6-pentafluorobenzene

生成物 1

HCID 15272444HCID 15272444、化合物収率 96%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Perfluorobenzyl bromide (2.00 g, 7.66 mmol) and P(OEt)3 (1.66 g, 9.96 mmol) were dissolved in 1,4-dioxane (10 ml) and heated at reflux for 14 hours. Fractional distillation (66-78° C., 60 mm Hg) afforded the product as a colorless oil (2.43 g, 96%)

後処理

  1. temperatureheated
  2. temperatureat reflux for 14 hours
  3. distillationFractional distillation (66-78° C., 60 mm Hg)

出典と根拠

ORDレコード
ord-e0e4836cc265494fa478fbe0610d056e
出典データセット
uspto-grants-2013_03
特許番号
US08405069B2

反応ノート

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