Formic Acid → Methyl 5-formyl-3-methylthiophene-2-carboxylate

HRID 1952562ノート

反応式

HRID 1952562 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:11](OCC)[O:12]CC)=[CH:8][C:9]=1[CH3:10])=[O:4].C(O)=O>O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:11]=[O:12])=[CH:8][C:9]=1[CH3:10])=[O:4]

参加物

4

反応物 2

HCID 284Formic AcidHCID 682264465-Diethoxymethyl-3-methyl-thiophene-2-carboxylic acid methyl ester

生成物 1

HCID 57618829Methyl 5-formyl-3-methylthiophene-2-carboxylate収率 100%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
0 °C

実験手順

A solution of 5-diethoxymethyl-3-methyl-thiophene-2-carboxylic acid methyl ester (4.41 g, 17.1 mmol) in dioxane (20 ml) was cooled to 0° C. (ice bath). 88% formic acid (40 ml) was added in one portion and the mixture was stirred at 0° C. for 5 min and then at rt for 30 min. The mixture was concentrated under reduced pressure to afford the desired product which was not further purified (3.2 g, 100% yield).

後処理

  1. waitat rt for 30 min
  2. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-acb7632ba7dc4176b05e09c2efa6667f
出典データセット
uspto-grants-2013_03
特許番号
US08404859B2

反応ノート

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