Formic Acid → Methyl 5-formyl-3-(trifluoromethyl)-2-thiophenecarboxylate

HRID 1952575ノート

反応式

HRID 1952575 の反応式
[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:14](OCC)[O:15]CC)=[CH:8][C:9]=1[C:10]([F:13])([F:12])[F:11])=[O:4].C(O)=O>O1CCOCC1>[CH3:1][O:2][C:3]([C:5]1[S:6][C:7]([CH:14]=[O:15])=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13])=[O:4]

参加物

4

反応物 2

HCID 284Formic AcidHCID 682265135-Diethoxymethyl-3-trifluoromethyl-thiophene-2-carboxylic acid methyl ester

生成物 1

HCID 71742491Methyl 5-formyl-3-(trifluoromethyl)-2-thiophenecarboxylate収率 99%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

反応条件

温度
0 °C

実験手順

A solution of 5-Diethoxymethyl-3-trifluoromethyl-thiophene-2-carboxylic acid methyl ester (2.72 g, 8.71 mmol) in dioxane (20 ml) was cooled to 0° C. (ice bath). 88% formic acid (25 ml) was added in one portion and the mixture was stirred at 0° C. for 5 min and then at rt for 60 min The reaction mixture was quenched by pouring into EtOAc. The organic layer was washed with water, dried over Na2SO4 and concentrated under reduced pressure to afford the desired product (2.05 g, 99% yield).

後処理

  1. customat rt for 60 min The reaction mixture was quenched
  2. additionby pouring into EtOAc
  3. washThe organic layer was washed with water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-779abd9d39f14d3d86c285b4561ec061
出典データセット
uspto-grants-2013_03
特許番号
US08404859B2

反応ノート

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