3-Cyanopyridine → 3-Pyridinecarboximidic acid, methyl ester
反応式
[C:1](#[N:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.C[O-].[Na+].[C:12](O)(=[O:14])C>CO>[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:1](=[NH:8])[O:14][CH3:12])[CH:3]=1参加物
5
実験手順
A solution of nicotinonitrile (11.35 g) and sodium methoxide (1.1 g) in methanol was allowed to stand at ambient temperature under nitrogen for 18 hours, then acetic acid (1.2 ml) was added, and the solvent was removed in vacuo. The residue was triturated with cyclohexane, undissolved solid was removed by filtration, and the solvent was removed in vacuo to leave methyl pyridine-3-carboximidate as an orange oil (10.6 g).
後処理
- customthe solvent was removed in vacuo
- customThe residue was triturated with cyclohexane, undissolved solid
- customwas removed by filtration
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-4c206c5bd049428ca5840ce598c209d9
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06114334
反応ノート
読み込み中…