Hydrochloric Acid → 5-Methylfuran-3-carboxylic acid
反応式
[CH3:1][C:2]1[O:6][CH:5]=[C:4]([C:7]([O:9]CC)=[O:8])[CH:3]=1.[OH-].[K+].Cl>O>[CH3:1][C:2]1[O:6][CH:5]=[C:4]([C:7]([OH:9])=[O:8])[CH:3]=1参加物
5
反応条件
- 温度
- 10 °C
実験手順
A mixture of 31.7 g (206 mmol) of ethyl 5-methylfuran-3-carboxylate, 40 ml of 45% strength potassium hydroxide and 100 ml of water was refluxed for 4 h, then cooled to 10° C. and acidified to pH 1 with 15% strength hydrochloric acid. The resulting mixture was left at this temperature for 2 h, and the precipitate was filtered off and dried to constant weight at 45-50° C., resulting in 23.7 g (188 mmol, 91%) of 5-methylfuran-3-carboxylic acid.
後処理
- temperaturewas refluxed for 4 h
- filtrationthe precipitate was filtered off
- customdried to constant weight at 45-50° C.
出典と根拠
- ORDレコード
- ord-7840415ec1db4da8883176945e9f6a36
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06114358
反応ノート
読み込み中…