4-Isopropylaniline → 2-[(4-Isopropyl)phenylamino]isophthalic acid

HRID 1952877

反応式

I[C:2]1[C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH:14]([C:17]1[CH:23]=[CH:22][C:20]([NH2:21])=[CH:19][CH:18]=1)([CH3:16])[CH3:15]>>[CH:14]([C:17]1[CH:23]=[CH:22][C:20]([NH:21][C:2]2[C:10]([C:11]([OH:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])=[CH:19][CH:18]=1)([CH3:16])[CH3:15]

参加物

反応物 2

HCID 74644-Isopropylaniline

HCID 3201002-Iodoisophthalic Acid

生成物 1

HCID 107328852-[(4-Isopropyl)phenylamino]isophthalic acid収率 62%

実験手順

Similar reaction of 2-iodoisophthalic acid and 4-isopropylaniline gave 2-[(4-isopropyl)phenylamino]isophthalic acid (62%), mp (EtOAc/petroleum ether) 208° C. (dec). 1H NMR [(CD3)2SO] δ 1.16 (d, J=6.9 Hz, 6 H, 2×CH3), 2.78-2.82 (m, 1 H, CH), 6.83 (d, J=8.4 Hz, 2 H, H-2' and H-6' or H-3' and H-5'; 6.97 (t, J=7.7 Hz, 1 H, H-5), 7.07 (d, J=8.5 Hz, 2 H, H-3' and H-5' or H-2' and H-6'), 7.92 (d, J=7.7 Hz, 2 H, H-4 and H-6), 9.66 (br s, 1 H, NH), 12.89 (br s, 2 H, 2×COOH). Anal. (C17H17NO4) C, H, N.

出典と根拠

ORDレコード: ord-a8fb4f9941354aa4a2e2f30158bbcc74
出典データセット: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06114332

反応式

参加物

反応物 2

生成物 1

実験手順

出典と根拠

関連ノート