Hydrochloric Acid → 2-(Hydroxyimino)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

HRID 1952968ノート

反応式

HRID 1952968 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH2:7][CH2:6]2.[N:15](OCCC(C)C)=[O:16].Cl>C(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[C:7](=[N:15][OH:16])[CH2:6]2

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 8053Isoamyl NitriteHCID 750185,6-Dimethoxy-1-indanone

生成物 1

HCID 67540042-(Hydroxyimino)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

5,6-Dimethoxy-1-indanone (0.078 moles, 15 g) is dissolved in absolute ethanol (550 ml), thermostated at 50° C., and added with isoamyl nitrite (0.086 moles, 11.9 ml) and conc. HCl (11.9 ml). After a few minutes the product precipitates. The reaction is kept at 50° C. for further 3 hours, then cooled at r.t. and the solid is filtered washing with absolute ethanol (50 ml) and ethyl ether (100 ml). The product is dried in oven under vacuum at r.t. Yield: 16.3 g (94.4%)

後処理

  1. customAfter a few minutes the product precipitates
  2. filtrationthe solid is filtered
  3. washwashing with absolute ethanol (50 ml) and ethyl ether (100 ml)
  4. customThe product is dried in oven under vacuum at r.t

出典と根拠

ORDレコード
ord-d936209124fc4f798932fc5b440e1bda
出典データセット
uspto-grants-2000_09
特許番号
US06114391

反応ノート

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