Phosphorus pentachloride → 2-Chloro-1-methyl-5-nitro-1H-benzimidazole

HRID 1953261ノート

反応式

HRID 1953261 の反応式
P(Cl)(Cl)(Cl)(Cl)[Cl:2].[N+:7]([C:10]1[CH:20]=[CH:19][C:13]2[N:14]([CH3:18])[C:15](=O)[NH:16][C:12]=2[CH:11]=1)([O-:9])=[O:8]>P(Cl)(Cl)(Cl)=O>[N+:7]([C:10]1[CH:20]=[CH:19][C:13]2[N:14]([CH3:18])[C:15]([Cl:2])=[N:16][C:12]=2[CH:11]=1)([O-:9])=[O:8]

参加物

4

反応物 2

HCID 24819Phosphorus pentachlorideHCID 6063051-Methyl-5-nitro-1,3-dihydro-2H-benzimidazol-2-one

生成物 1

HCID 108223912-Chloro-1-methyl-5-nitro-1H-benzimidazole

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

反応条件

温度
125 °C

実験手順

2.1 g (0.01 mol) of phosphorus pentachloride are dissolved in 2.5 ml phosphorus oxychloride and after the addition of 1.9 g (0.01 mol) of 5-nitro-1-methyl-benzimidazol-2-one the mixture is stirred for two hours at 125° C. The solvent is evaporated off, the residue is poured onto ice water and neutralised with ammonia. The precipitate formed is suction filtered and dried.

後処理

  1. customThe solvent is evaporated off
  2. additionthe residue is poured onto ice water and neutralised with ammonia
  3. customThe precipitate formed
  4. filtrationfiltered
  5. customdried

出典と根拠

ORDレコード
ord-34226644c38e457ebf81005291fb39db
出典データセット
uspto-grants-2000_09
特許番号
US06114532

反応ノート

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